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Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis.
Neuwirt H, Bouchal J, Kharaishvili G, Ploner C, Jöhrer K, Pitterl F, Weber A, Klocker H, Eder IE. Neuwirt H, et al. Cell Commun Signal. 2020 Jan 24;18(1):11. doi: 10.1186/s12964-019-0505-5. Cell Commun Signal. 2020. PMID: 31980029 Free PMC article.
In particular, two genes, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (HMGCS2) and aldo-keto reductase family 1 member C3 (AKR1C3), were significantly upregulated in PCa cells upon co-culture with CAFs. Both enzymes were also significantly increased in human PCa compa …
In particular, two genes, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (HMGCS2) and aldo-keto reductase family 1 member C3 (AKR1C …
Short-term high fat diet alters genes associated with metabolic and vascular dysfunction during adolescence in rats: a pilot study.
Mohr AE, Reiss RA, Beaudet M, Sena J, Naik JS, Walker BR, Sweazea KL. Mohr AE, et al. PeerJ. 2021 Jul 9;9:e11714. doi: 10.7717/peerj.11714. eCollection 2021. PeerJ. 2021. PMID: 34285833 Free PMC article.
METHODS: RNA was extracted from the aorta of eight rats from a larger experiment; four animals fed a high-fat diet (HFD) known to induce symptoms of metabolic dysfunction (hypertension, increased adiposity, fasting hyperglycemia) and four age-matched healthy animals fed a …
METHODS: RNA was extracted from the aorta of eight rats from a larger experiment; four animals fed a high-fat diet (HFD) known to induce sym …
Mitochondrial HMG-CoA synthase partially contributes to antioxidant protection in the kidney of stroke-prone spontaneously hypertensive rats.
Yi W, Fu P, Fan Z, Aso H, Tian C, Meng Y, Liu J, Yamori Y, Nara Y, Ying C. Yi W, et al. Nutrition. 2010 Nov-Dec;26(11-12):1176-80. doi: 10.1016/j.nut.2009.10.010. Epub 2010 Feb 4. Nutrition. 2010. PMID: 20137896
We explored the role of renal mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMGCS2) expression, a key control site of ketogenesis, in stroke-prone spontaneously hypertensive rats (SHRSPs) and their ancestral hypertensive but stroke-resistant s …
We explored the role of renal mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMGCS2) expression, a key control site of …
Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients.
Singh S, McDonough CW, Gong Y, Alghamdi WA, Arwood MJ, Bargal SA, Dumeny L, Li WY, Mehanna M, Stockard B, Yang G, de Oliveira FA, Fredette NC, Shahin MH, Bailey KR, Beitelshees AL, Boerwinkle E, Chapman AB, Gums JG, Turner ST, Cooper-DeHoff RM, Johnson JA. Singh S, et al. J Am Heart Assoc. 2018 Mar 9;7(6):e007339. doi: 10.1161/JAHA.117.007339. J Am Heart Assoc. 2018. PMID: 29523524 Free PMC article.
G-allele carriers of HMGCS2 had higher glucose levels (glucose change=+16.29 mg/dL) post chlorthalidone treatment compared with noncarriers of G allele (glucose change=+2.80 mg/dL). ...CONCLUSIONS: These results suggest that HMGCS2 is a promising candidate gene invo …
G-allele carriers of HMGCS2 had higher glucose levels (glucose change=+16.29 mg/dL) post chlorthalidone treatment compared with nonca …
Streptozotocin diabetes increases mRNA expression of ketogenic enzymes in the rat heart.
Cook GA, Lavrentyev EN, Pham K, Park EA. Cook GA, et al. Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):307-312. doi: 10.1016/j.bbagen.2016.11.012. Epub 2016 Nov 11. Biochim Biophys Acta Gen Subj. 2017. PMID: 27845231 Free PMC article.
Increased mRNA expression for these enzymes was confirmed by RTQ PCR. The mRNA encoding HMGCS2, the rate-controlling enzyme, was 27 times greater in diabetic hearts. Total HMGCS2 protein increased 8-fold in diabetic hearts, but no difference was found in HMGCS2 …
Increased mRNA expression for these enzymes was confirmed by RTQ PCR. The mRNA encoding HMGCS2, the rate-controlling enzyme, was 27 t …
Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: role of fetal exposure to {beta}-hydroxybutyrate.
Langley-Evans SC, Daniel ZC, Wells CA, Ryan KJ, Plant R, Welham SJ. Langley-Evans SC, et al. Exp Physiol. 2011 Feb;96(2):203-15. doi: 10.1113/expphysiol.2010.054460. Epub 2010 Sep 17. Exp Physiol. 2011. PMID: 20851857 Free article.
Maternal undernutrition during sensitive periods of pregnancy results in offspring predisposed towards the development of a number of diseases of adulthood, including hypertension and diabetes. In order to determine the nature of any gross alterations in fetal growth durin …
Maternal undernutrition during sensitive periods of pregnancy results in offspring predisposed towards the development of a number of diseas …